Sex- and species-dependent difference of methoxychlor O-demethylation by rat and mouse liver microsomes
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چکیده
منابع مشابه
Metabolic Difference of CZ48 in Human and Mouse Liver Microsomes
CZ48, chemically camptothecin-20-O-propionate hydrate, is currently under clinical investigation. The kinetics of the metabolite camptothecin (CPT) formation and of CZ48 depletion in mouse and human liver microsomes in the presence or absence of NADPH was examined. The formation rate of camptothecin in human liver microsomes was significantly higher than that in mouse with mean K(m)s of 1.9 and...
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Benzo(a) pyrene is a carcinigen polycyclic aromatic hydrocarbon which diffuses into the environment from combustion of organic meterials.based on various epidemiological evidences it is related to lung,skin and liver cancer.mutagenicity,and immunosuppressivety are among important biological effects of Benzo(a) pyrene.after absorbtion and distribution in the body,it undergoes epoxidation by cyto...
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The activities of testosterone hydroxylases and erythromycin N-demethylase were significantly higher in liver microsomes from female hamsters than in the male counterparts. SDS-polyacrylamide gel electrophoresis revealed a difference in protein composition between male and female liver microsomes in the molecular mass region comprising cytochrome P-450. Western blot analysis showed further that...
متن کاملMetabolism of dacarbazine by rat liver microsomes contribution of CYP1A enzymes to dacarbazine N-demethylation
The N-demethylation of dacarbazine in liver microsomes was significantly increased by treatment of rats with b-naphthoflavone, dexamethasone, or phenobarbital. However, the extent of increase in the N-demethylation observed in b-naphthoflavone-treated rats was much greater than that observed in dexamethasone-treated rats. A good correlation between N-demethylation of dacarbazine and O-deethylat...
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ژورنال
عنوان ژورنال: Journal of Pesticide Science
سال: 2006
ISSN: 1348-589X,1349-0923
DOI: 10.1584/jpestics.31.102